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Stockley's Drug Interactions: A Source Book of Interactions, Their Mechanisms, Clinical Importance and Management

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"This incredibly detailed text is a must have for toxicologists who spend much time reviewing the known and potential effect of drugs when detected together......Like other Pharmaceutical Press publications (eg Clarke's Analysis of Drugs and Poisons) this quality publication provides an evidence based assessment of drugs and their interactions. The monographs are methodically set out providing the relevant clinical evidence of the drugs interaction, the mechanism, the significance of the findings as well as the management of clinical symptoms. All of the monographs are referenced with up to date reviews on available literature......contains in-depth yet concise monographs in an easy-to-read format and provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance, and clear guidance on managing the interaction in practice. The coverage of drugs is impressive, including drugs that are used around the world not just from a national jurisdiction......I can recommend this text for all toxicologists as it provides an authoritative and evidence based approach to documented drug interactions - an approach we should always maintain when interpreting our casework."Dimitri Gerostamoulos, TIAFT bulletin, 46(2) June 2016 (Dimitri Gerostamoulos TIAFT Bulletin)"In 2008 and 2014 we reviewed the pocket edition of this major Reference Book, and were impressed...The 'big' Stockley's remains 'the' famous reference work that provides concise and rather complete information on clinically relevant drug-drug interactions (DDIs). It provides health care professionals with practical information on medicines interactions and their management...Stockley's is still indispensable for the clinical pharmacist. It is a very reliable publication which is kept up to date." J.W.F. van Mil, International Journal of Clinical Pharmacy.

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From the Back Cover

Stockley’s Drug Interactions, edited by Claire L Preston, remains the world’s most comprehensive and authoritative international reference book on drug interactions. Based upon thousands of published papers and reports it: * Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, and drugs of abuse * Contains in-depth yet concise monographs in an easy-to-read format * Provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance, and clear guidance on managing the interaction in practice * Has a brief summary of the interaction in each monograph – perfect for the busy healthcare professional * Is fully referenced throughout * Contains almost 4500 monographs * Is global in coverage – inclusion of drugs used worldwide New in the 11th edition: * Over 350 new monographs added * Many existing monographs have been reviewed, revalidated, and updated * A comprehensive update and restructure of the chapter on Antidiabetic drugs, in-line with published literature * Addition of new advice regarding the concurrent use of aliskiren, ACE inhibitors, and angiotensin-II receptor antagonists * An updated list of drugs that have a risk of prolonging the QT interval * The addition of new drugs, including apixaban, apremilast, dolutegravir, lomitapide, mirabegron, the NS5A inhibitors (daclatasvir, ledipasvir, ombitasvir), the NS5B inhibitors (dasabuvir, sofosbuvir), the sodium-glucose co-transporter-2 inhibitors (canagliflozin, dapagliflozin, empagliflozin), and telavancin From the reviews of previous editions: "...well written and heavily referenced. Students would find the introduction very helpful to understanding the concepts of drug interactions...great reference for drug information departments and pharmacists..." Annals of Pharmacotherapy "...comprehensive in its scope...presents a thorough overview of the varied possible drug interactions that exist...a well-organized reference text." Journal of the Medical Library Association "...This is an extremely useful book. The information is thorough, concise, clinically relevant, and referenced to the primary literature." Doody Enterprises, Inc.

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Series: Stockley's Drug Interactions

Hardcover: 2048 pages

Publisher: Pharmaceutical Press; 12th Revised edition edition (March 11, 2019)

Language: English

ISBN-10: 085711347X

ISBN-13: 978-0857113474

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Paperback: 205 pages

Publisher: Independently published (March 11, 2019)

Language: English

ISBN-10: 1798208490

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Download To the Edge of the World: The Story of the Trans-Siberian Express, the World's Greatest Railroad, by Christian Wolmar

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About the Author

Christian Wolmar is a writer and broadcaster, specializing in transportation matters. He has written for major British newspapers for many years and has contributed to many other publications, including the New York Times and Newsday. His most recent books are Blood, Iron, and Gold; Engines of War; and The Great Railroad Revolution. He lives in London.

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Product details

Paperback: 320 pages

Publisher: PublicAffairs; Reprint edition (April 5, 2016)

Language: English

ISBN-10: 1610396367

ISBN-13: 978-1610396363

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5.8 x 0.9 x 9.1 inches

Shipping Weight: 13.6 ounces (View shipping rates and policies)

Average Customer Review:

4.1 out of 5 stars

41 customer reviews

Amazon Best Sellers Rank:

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I'm amazed at the lack of citations from an author who claims on the dust jacket to have "written for major British newspapers", author of numerous other books and "specializing in transportation matters". Firstly, even though he mentions the Treaty of Portsmouth (end of Russo-Japanese War) that was negotiated in Portsmouth, New Hampshire, he says it was in "Maine" and neither editor nor publisher were attentive enough to catch this very simple and well-known fact. Right there I started wondering what other "facts" were in question. For example, on p. 160 he writes: "...there were no clear accounts of the cost [of the railway construction] kept by the government" (which I don't believe at all), then contradicts his own statement a number of times: on p. 127 he claims the "Chinese Eastern Railway cost $400 million rubles (40,000 pounds)" with NO CITATION and then on p. 135 that the "Circum-Baikal cost 70 million rubles" with NO citation and on p.170 he claims, again without citation, that the "Amur Line cost 400 million rubles (40,000 pounds)" -- strangely the exact same cost as the Chinese Eastern Railway. Also, he never touches on the origins of the rail and locomotives. I know that most of the locomotives and rail (rolling stock) were purchased from Germany and the US, but NEVER ONCE does the author mention any information about this -- even though he says he's a "broadcaster specializing in transportation matters." Why not tell us about the types of locomotives and where they were purchased? He says he and his wife journeyed on the Trans-Siberian and there's a cute little picture of the 2 of them in the book, yet no description of the journey, no unique insight or local color, nothing that would give the reader the impression that he's actually been there and is any more an expert than someone who's read a few books (Orlando Figes is quoted endlessly) and compiled what he read in a manuscript. Also, I believe that the Trans-Siberian was financed with French loans--rather an important point that I was looking to confirm, but NO MENTION of this. In fact no mention of the financing at all, I guess since he already claimed that the Tsarist Government didn't keep records (PLEASE!) he didn't bother to research that issue. Yet he goes on and on about the food and other minutia, again without any citations at all. Wolmar also gives too much personal opinion about the demise of White forces during the civil war, which had no business in this book since this is a complicated subject that has been covered by actual historians elsewhere. Overall, super disappointed that this book was just a chatty manuscript with little reliable information that neither author, editor nor publisher cared to check before selling to the public.

If you like well-written history, if you're interested at all in 20th-century Russia/Soviet Union, if you're into trains & the histories thereof, this book is for you. Thoroughly researched, elegantly written, measured & fair in its judgments, "To the Edge of the World" was a fascinating account of the history of the Trans-Siberian Railway. I rode the length of the railway this summer and took this book along, although I didn't end up reading it till after I was home. I wish I'd read it beforehand (or during), as I would have had a better appreciation for the monumental achievement that it is and for just how much history, much of it grim, played out along this line. One more thing: I read the Kindle version. I wish I'd had the hard copy, as the maps & images on Kindle were just not user-friendly.

This is a great book describing much about the Trans-Siberian Railway. The best parts involve the political consequences of the project. I found the stuff about the Russo-Japanese war (and the railway's role in it) very interesting as were the parts about the Russian revolution. For my tastes there was too little about the technical problems of building the railway. But if you're interested in a sweeping overall view, this is a nice compromise.

I enjoy history very much and revel in the minutia of how things get done. So this book delivered on those points. I think I would have liked to know more about the actual construction of the railroad as well as the politics of the construction of the railroad. I guess history buffs are never satisfied. It is very apparent that public works projects always get bogged down in bureaucracy. Times haven't changed that much! I enjoyed reading this book and only the jumping around the timeline made it not 5 stars for me.

Mr. Wolmar tells an interesting story about the Trans-Siberian railroad. The detail he describes in building the railroad and and his descriptions of the harsh terrain that the railroad follows is fascinating. However at times he becomes too detailed as to the intricacies of financing of the railroad and some of the personalities that are involved. All in all it was an interesting book.

A another fine book on railroads, by this author. I have read other books he has written and they all do good credit to his subjects. Not as in depth, however he has a good overview of this road.

Not a travel book but a real history of the longest Rail line in the world. Wanting to take the train now more than ever. On my bucket list

Christian Wolmar is one of the world's leading authors about rail travel for a host of reasons; his research is impeccable, his presentation keeps the pages turning.

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File Size: 98676 KB

Print Length: 256 pages

Publisher: DC Comics (October 7, 2014)

Publication Date: October 7, 2014

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Batman Vol. 5 Zero Year-Dark City collects two of the final story arcs for Zero Year; Dark City (issues 25-27) and Savage City (#29-33). This is the conclusion of the three-part story arc major crossover origin event known as Zero Year. Dark City picks up after the events in the first story arc of Zero Year, Secret City, after Batman has stopped the Red Hood Gang and the Riddler shuts off all the power in Gotham City. We see the reintroduction of the classic GCPD blimps from Batman the Animated Series, which is awesome to see, as they comb the city searching for any sign of Batman. But, Batman has a new case on his hands involving a killer who uses a serum that causes uncontrolled bone growth. Batman discovers the villain, known as Dr. Death (who was Batman’s first major supervillain he fought in DC Comics, the Joker was the first villain Batman faced in his own comic book series) and both Death and the Riddler team up to seize control of Gotham during superstorm Rene which threatens to cause even more problems for the powerless and crippled Gotham City. In Dark City, more is explained about Bruce’s opinions of Lt. Gordon and why he doesn’t trust the police lieutenant. We also see more backstory involving Bruce as a child and his parents leading up to the fateful night in Crime Alley. Dr. Pamela Isley also has a cameo appearance in this arc but her research will later impact the look of Gotham in the next story arc. Savage City takes place several days after the events in Dark City. It is now, Zero Year: the new calendar year according to Edward Nygma. Using Isley’s research Riddler has turned Gotham into an overgrown barren wasteland and his demands for Gotham is quite simple: get smart, or die. Every sunset, the Riddler on a giant screen in Gotham and challenges any brave citizen to ask a riddle that he can’t solve. No one has been successful. Bruce can’t retrieve any of his suits or gadgets from the cave so he must improvise and create a torn and tattered costume and tools to help him mount a counterattack against the Riddler. Batman enlists the help of trustworthy allies who are trying to fight against the Riddler, specifically Lucius Fox and Lt. Gordon. The team is also joined by a special covert military assault force as well. But time becomes the enemy as jets threaten to bomb Gotham, doing exactly what the Riddler intended and sending Gotham crashing down all around. Batman and his team must work together to stop the Riddler and survive Zero Year. Scott Snyder’s writing is still great. The characterization of these characters is both refreshing and still honors the source material, which Snyder is very good at doing. The interaction between Bruce and Alfred is very special and very well written. Bruce’s relationship with Gordon changes drastically in these final arcs and it makes sense why Bruce finally throws off his uncertainty about Gordon and accepts him as an ally going forward. The story appeared to take a lot of inspiration from The Dark Knight Rises and the video game The Last of US (both can be seen in the Savage City story arc). The inclusion of Dr. Death as one of Batman’s first villains, just like in the original comics, was amazing. Snyder really got to show off his horror writing here with gorgeous yet very visceral character design for Dr. Death by Greg Capullo. Speaking of Greg Capullo, he hasn’t lost his touch at all. Gotham is very vibrant and well defined as well as people are all distinctively drawn. Capullo always brings his unique style to many of these characters which I enjoy, it definitely sets his work apart from other artists. We see many new vehicles a Bat-blimp, a proto-Batmobile race car, and the Bat-boat. All of them are beautiful to look at and are drawn with great detail. Danny Miki and FCO Plascencia make Capullo’s art look absolutely gorgeous and very vibrant and colorful as well. Batman Vol. 5 is a great ending to the masterpiece of an origin story retelling. To me, this will be my favorite Batman origin story, not because it’s new and I very much enjoy Snyder and Capullo’s run on the character, but because, like Year One when it was written, Zero Year speaks to us in the 21st Century. Zero Year addresses our anxieties our struggles and places Batman’s emergence in the midst of all of those things to show us how truly great a hero he is.

Now, I can't automatically say that this book or these books by this writer and artist team is going to be for everyone. These books can be awfully wordy and dense and that might turn a lot of people off from the stories, but you get the most bang for your buck in these trades. It's masterful. Just the storytelling alone is refreshing, inspiring, and cinematic.You can study and analyze this book, and explore the themes in this story. The writing lends itself to it almost intentionally. Very well crafted writing from Snyder. This book is a continuation of the zero year arc from the batman series, where the riddler reeks havoc in Gotham. This book certainly highlights how menacing and dangerous the Riddler actually is and actually can be. This is certainly a set up from what we are use to seeing from him. This isn't the simple nerdy villain that puts batman in traps. This is a book shows you why the Riddler will and will always be one batman's greatest villains.One of the best Riddler stories and interpretations of the character I have ever seen. The art in of itself is beyond impressive, and stories in of itself. The designs of characters, the expressions, the action, the symbols, it's so beautiful to the point where I want to hang each page as a poster in my room. You have one of the best artists in the industry working on this book, and you get a lot from him. I actually think we get to see a lot of this artwork shine because the story lends itself to it. A great continuation to the series. I mean just the idea of Gotham falling into his almost apocalyptic ruin is fascinating in of itself which I think would be amazing to see adapted in a feature film. It's no surprise that Snyder and Capullo are able to give us another satisfying story. This is certainly a book and series that benefits from a re-reading. This isn't just another story to read to see what happens next. This is a well crafted story from top to bottom, with twist and turns that raise the bar in every issue. There is so much detail being put into this book, where you have to read this a second time just to get better sense of everything going on to not do the writing a disservice. This is certainly the most satisfying book of the series yet. I feel like I got more from this book than I would have in most comic books. I'm actually planning on buying this book again in paperback form just for collection and personal use because of how great this book is. It's certainly a classic in my eyes, so this is a must own. It's well worth your money. You will get more out of this book than you will from most. Books like these is why comics and writing inspire me. It goes without saying that I recommend you reading this series. If you aren't, you are missing out on something that is truly great, something that will last. Classic batman story.

Following directly on from New 52 Batman Vol.4, Volume 5 brings the Zero Year storyline to a close. With the Red Hood defeated, The Riddler is now the supreme criminal power in Gotham City, holding it in a death grip and making its citizenry dance to his own tune by posing daily riddles for his own amusement. There are shades of Christopher Nolan's third "Dark Knight" movie in the plotting, which portrays a Gotham City cut off from the outside world and lorded over by a megalomaniac. Of course, Batman is the city's only hope, and it's hardly a spoiler to say that he wins the day in the end, but it is not an easy victory and it is not without cost. Seeing exactly how this all plays about is the biggest delight of the program, and writer Scott Snyder does not disappoint. It's a dark and gritty Batman tale that ties up the loose ends of Zero Year rather neatly. I enjoyed it a lot more than the first volume, which was still very good in its own right, and I'm looking forward to Volume 6.

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